| 摘要 |
PCT No. PCT/FR94/00992 Sec. 371 Date Mar. 28, 1996 Sec. 102(e) Date Mar. 28, 1996 PCT Filed Aug. 9, 1994 PCT Pub. No. WO95/04772 PCT Pub. Date Feb. 16, 1995The present invention relates to a method for the preparation of polyamino acids, with controlled molecular weights, by polymerization of N-carboxyanhydrides (NCAs) of at least one amino acid, using at least one initiator of the strong base type and in liquid medium, characterized in that it consists in including, in the liquid reaction medium, given amounts of water and/or of alcohol. Application: synthesis of polyamino acids with mechanical and rheological characteristics adapted to applications as biomaterials.
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