摘要 |
Compounds of general formula (1): <IMAGE> (1) are described wherein =W- is (1) =C(Y)- where Y is a halogen atom, or an alkyl, or -XaR1 group where Xa is -O-, -S(O)m- [where m is zero or an integer of value 1 or 2], or -N(Ra)- [where Ra is a hydrogen atom or an optionally substituted alkyl group] and R1 is a hydrogen atom or an optionally substituted alkyl group or, (2) =N-; X is as described above for Xa or is a chain -CR=C(Rb)- or [-CH(R)]q-CH(Rb)- where R is a hydrogen or a fluorine atom or a methyl group, Rb is as described below for R2 and q is zero or the integer 1; R2 is (1) an optionally substituted alkyl, alkenyl, cycloalkyl or cycloalkenyl group when X is -O-, -S(O)m- or -N(Ra)-; atoms or groups; R3 is an atom or group R13; R4 is a hydrogen atom or is as defined for R6; R5 is a hydrogen or a fluorine atom; R6 is a group -(CH2)nAr where Ar is an optionally and R8, which may be the same or different, is a hydrogen or a fluorine atom, or an optionally substituted straight or branched alkyl group; and the salts, solvates, prodrugs, hydrates and N-oxides thereof. Compounds according to the invention are phosphodiesterase type IV inhibitors and are useful in the prophylaxis and treatment of disease such as asthma where an unwanted inflammatory response or muscular spasm is present.
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