| 摘要 |
FIELD: organic chemistry. SUBSTANCE: invention describes compounds of the formula (I) <EMI ID=0.38 HE=33 WI=30 TI=CHI> where R and R - independently hydrogen, halogen, CF<SB>3</SB>, CN, NO<SB>2</SB> or group SO<SB>2</SB>NR<SP>1</SP>R where R - hydrogen or C<SB>1</SB>-C<SB>6</SB>-alkyl that can be branched or cyclic; R - hydrogen or C<SB>1</SB>-C<SB>6</SB>-alkyl that can be normal, branched or cyclic or where R and R form together group -(CH<SB>2</SB>)<SB>n</SB>-A-(CH<SB>2</SB>)<SB>m</SB> where A - O, S, CH<SB>2</SB> or NR where R - H, C<SB>1</SB>-C<SB>6</SB>-alkyl that can be normal, branched or cyclic; n = 0, 1, 2, 3, 4, 5 and m = 0, 1, 2, 3, 4, 5; Q - NOH or O; Z - O, S, N-R , -C(O)-NR<SP>III</SP>-, N-Q -C(O)-N-R -, -C(O)- where R<SP>II</SP>,R<SP>III</SP>,R<SP>IV</SP>,R - independently - hydrogen, benzyl, C<SB>1</SB>-C<SB>6</SB>-acyl, C<SB>1</SB>-C<SB>6</SB>-alkoxyl that can be branched or cyclic, or C<SB>1</SB>-C<SB>6</SB>-alkyl that can be branched or cyclic; X - -(CH<SB>2</SB>) where o = 0, 1, 2 or 3; Y - -(CH<SB>2</SB>)<SB>p</SB> where p = 0, 1, 2 or 3; alpha ¿ beta - addition points. Invention describes pharmaceutical composition showing activity associated with blockade of glutamic and aspartic acid receptors using the synthesized compounds. EFFECT: improved method of synthesis. 9 cl |
