MAMMALIAN EQUILIBRATIVE NUCLEOSIDE TRANSPORTERS

摘要

The invention provides substantially purified equilibrative nucleoside transporter polypeptide, and polynucleotides encoding ENTs. Antibodies which bind equilibrative nucleoside transporter polypeptide and formulations for administration of these antibodies are also disclosed. Methods for identifying a compound which affects an equilibrative nucleoside transporter, and for determining if a compound utilizes an equilibrative nucleoside transporter are provided. A method of assessing a therapeutic intervention for a subject, where the effectiveness of the therapeutic intervention is correlated with the presence or absence of an equilibrative nucleoside transporter, is provided. A method of treating a subject having or at risk of having a disorder associated with an equilibrative nucleoside transporter is also disclosed. Kits for detecting the presence of an equilibrative nucleoside transporter are provided. Transgenic animals having a transgene encoding an equilibrative nucleoside transporter are described.