DRUGS FOR AMELIORATING OPHTHALMIC CIRCULATORY DISTURBANCE

摘要

Drugs for ameliorating ophthalmic circulatory disturbance characterized by containing as the active ingredient potassium channel openers. As the potassium channel openers, use may be preferably mado of carboxyimidamide derivatives represented by general formula (I), acid-addition salts thereof or hydrates of the same, wherein each symbol is as defined in the specification. When dropped into eyes, in particular, drugs for ameliorating ophthalmic circulatory disturbance containing the compounds of general formula (I) can increase the blood flow in the optic papillae of normal eyes and inhibit retinal vessel contraction and a decrease in the blood flow in the optic papillae of eyes suffering from circulatory disturbance caused by ET-1 while scarcely affecting the blood pressure. It is therefore suggested that these compounds are useful as remedies for glaucoma, in particular, normotensive glaucoma caused by ophthalmic circulatory disturbance, retinal pigment degeneration, macular degeneration, ischemic optic nerve disease, iridocyclitis, retinal arterial obliteration, retinal phlebemphraxis, diabetic retinopathy, ischemic optic nerve disease, choroid diseases following retinal lesions, retinal choroid diseases accompanied by systemic diseases, etc.