发明名称 |
TISSUE TYPE PLASMINOGEN ACTIVATOR (T-PA) VARIANTS: COMPOSITIONS AND METHODS OF USE |
摘要 |
Variants of tissue plasminogen factor exhibit significantly enhanced fibrin stimulation, dramatically increased discrimination among fibrin co-factors, marked resistance to inhibition by PAI-1, and substantially increased zymogenicity, a combination of properties that enhance the therapeutic utility of the enzyme. |
申请公布号 |
WO9821320(A3) |
申请公布日期 |
1998.07.09 |
申请号 |
WO1997US20226 |
申请日期 |
1997.11.12 |
申请人 |
THE SCRIPPS RESEARCH INSTITUTE;MADISON, EDWIN, L. |
发明人 |
MADISON, EDWIN, L. |
分类号 |
G01N33/53;A61K38/00;C12N5/10;C12N9/64;C12N9/72;C12N15/09;C12Q1/68;C12R1/91 |
主分类号 |
G01N33/53 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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