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发明名称 INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE
摘要 The present invention is directed to compounds which inhibit farnesyl-protein transferase (FTase) and the farnesylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for inhibiting farnesyl-protein transferase and the farnesylation of the oncogene protein Ras.
申请公布号 WO9829119(A1) 申请公布日期 1998.07.09
申请号 WO1997US23893 申请日期 1997.12.22
申请人 MERCK & CO., INC.;YOUNG, STEVEN, D.;ANTHONY, NEVILLE, J.;GRAHAM, SAMUEL, L.;TRAN, LEKHANH, O.;BELL, IAN, M.;DESOLMS, S., JANE;GOMEZ, ROBERT, P.;KUO, MICHELLE, SPARKS;LUMMA, WILLIAM, C., JR.;PERLOW, DEBRA, S.;SHAW, ANTHONY, W.;WAI, JOHN, S. 发明人 YOUNG, STEVEN, D.;ANTHONY, NEVILLE, J.;GRAHAM, SAMUEL, L.;TRAN, LEKHANH, O.;BELL, IAN, M.;DESOLMS, S., JANE;GOMEZ, ROBERT, P.;KUO, MICHELLE, SPARKS;LUMMA, WILLIAM, C., JR.;PERLOW, DEBRA, S.;SHAW, ANTHONY, W.;WAI, JOHN, S.
分类号 A61K31/4178;A61K31/437;A61K31/4439;A61K31/454;A61K31/497;A61P9/00;A61P13/12;A61P27/02;A61P31/12;A61P35/00;A61P43/00;C07D401/10;C07D401/12;C07D401/14;C07D403/10;C07D403/14;C07D405/14;C07D417/14;C07D471/04;(IPC1-7):A61K31/44;C07D401/04;C07D213/22 主分类号 A61K31/4178
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