| 摘要 |
<p>Fused pyrimidine compounds represented by general formula (I), pharmaceutically acceptable salts thereof or hydrates of the same, drugs containing the compounds of general formula (I), pharmaceutically acceptable salts thereof or hydrates of the same, and medicinal compositions containing the compounds of general formula (I), pharmaceutically acceptable salts thereof or hydrates of the same, wherein each symbol is as defined in the specification. Because of having an excellent CRF receptor antagonism, these compounds are useful as drugs, in particular, remedies for human depression, eating disturbance including dietary negativism and overeating, Alzheimer's disease, schizophrenia, Parkinson's disease, Huntington's chorea, amyotrophic lateral sclerosis, mania, psychophysiologic disorder, senile dementia, panic disorder, cerebral attack, inflammation in autoimmune diseases such as rheumatoid arthritis, pain, obesity, Gilles de la Tourette's disease, alcohol dependence, climacteric disturbance and premenstrual tension syndrome, cardiac circulatory drugs such as hypotensive drugs, immunopotentiators, immunosuppressors and drugs for improving the conditions of patients in intensive care units (ICU).</p> |
