Drug flux enhancer-tolerant pressure sensitive adhesive composition

摘要

A drug flux enhancer-tolerant pressure sensitive adhesive composition comprises a mixture of (1) a percutaneous penetration enhancer to increase permeability of skin to transdermally administered pharmacologically active agents and (2) a macromer reinforced base polymer, said base polymer comprising a phase separated graft copolymer composition comprised of copolymerized monomers A and B forming a backbone polymer having polymeric moieties grafted thereto, wherein monomer A is a monomeric acrylic or methacrylic ester of a nontertiary alcohol having from 1 to 14 carbon atoms, with the average number of carbon atoms being in the range of 4 to 12, and a monomer B is a polar monomer which is copolymerizable with monomer A.