发明名称 |
Process for regioselective substitution of trifluorobenzoate or trifluorobenzonitrile |
摘要 |
The invention provides a process for regioselective substitution of trifluorobenzoate/trifluorobenzonitrile to afford the difluorobenzoate/difluorobenzonitrile in good yields. The resulting difluorobenzoate/difluorobenzonitrile can again be regioselectively substituted with a second nucleophile to give monofluorobenzoate/monofluorobenzonitrile also in good yields. This process is particularly useful for forming key intermediates in the synthesis of oxytocin antagonist compounds.
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申请公布号 |
US5777123(A) |
申请公布日期 |
1998.07.07 |
申请号 |
US19970806502 |
申请日期 |
1997.02.27 |
申请人 |
MERCK & CO., INC. |
发明人 |
LYNCH, JOSEPH E.;SHI, YAO-JUN;WELLS, KENNETH M. |
分类号 |
C07D211/46;C07D295/155;C07D413/14;(IPC1-7):C07D211/44;A61K31/445 |
主分类号 |
C07D211/46 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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