| 摘要 |
PROBLEM TO BE SOLVED: To obtain the subject composition capable of enhancing effects of either one of an angiotensin converting enzyme inhibitor and a calcium antagonist with each other and administration of the both is reduced without manifesting adverse effects, by making the composition include both the substances. SOLUTION: This pharmaceutical composition comprises (A) an angiotensin converting enzyme inhibitor or its physiologically permissible salt, ramipril 2-[N-(1,S-ethoxycarbonyl-3-phenylpropyl-S-alanyl]-(1S,3S,5S)-2- azabicyclo-[3.3.0]octane-3-carbonic acid} represented formula I and (B) a calcium antagonist or its physiologically permissible salt felodipine [4-(2,3- dichlorophenyl)-2,6-dimethyl-3-methoxycarbonyl-5-ethoxycarbonyl-1,4- dihydropyridine] represented by formula II at a ratio of e.g. 1-5 pts.wt. ingredient A to 15-1 pts.wt. ingredient B.
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