发明名称 |
Knockout mutant mouse for DARPP-32 and use thereof |
摘要 |
A knockout mouse containing a non-functional allele for the gene that naturally encodes and expresses functional DARPP-32 is disclosed. This mouse contains two non-functional alleles for the gene that naturally encodes and expresses functional DARPP-32, and therefore is unable to express functional DARPP-32. This mouse finds utility as a screening model for potential therapeutic agents useful in the treatment of schizophrenia, Parkinson's disease, and the treatment of addictions, especially those involving drugs of abuse.
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申请公布号 |
US5777195(A) |
申请公布日期 |
1998.07.07 |
申请号 |
US19960649103 |
申请日期 |
1996.05.17 |
申请人 |
THE ROCKEFELLER UNIVERSITY |
发明人 |
FIENBERG, ALLEN A.;GREENGARD, PAUL |
分类号 |
A61K49/00;C07K14/47;C12N15/85;(IPC1-7):C12N5/00;C12N5/06;C12N15/09 |
主分类号 |
A61K49/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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