| 发明名称 |
Epothilone analogs |
| 摘要 |
Epothilone A, epothilone B, analogs of epothilone and libraries of epothilone analogs are synthesized. Epothilone A and B are known anticancer agents that derive their anticancer activity by the prevention of mitosis through the induction and stabilization of microtubulin assembly. The analogs of epothilone are novel. Several of the anlogs are demonstrated to have a superior cytotoxic activities as compared to epothilone A or epothilone B as demonstrated by their enhanced ability to induce the polymerization and stabilization of microtubules. |
| 申请公布号 |
AU5757798(A) |
申请公布日期 |
1998.07.03 |
| 申请号 |
AU19980057577 |
申请日期 |
1997.12.12 |
| 申请人 |
NOVARTIS AG;THE SCRIPPS RESEARCH INSTITUTE |
发明人 |
COSTA KYRIACOS NICOLAOU;YUN HE;SACHA NINKOVIC;JOAQUIN PASTOR;FRANK ROSCHANGAR;FRANCISCO SARABIA;HANS VALLBERG;DIONISIOS VOURLOUMIS;NICOLAS WINSSINGER;ZHEN YANG;NIGEL PAUL KING;MAURICE RAYMOND VERSCHOYLE FINLAY |
| 分类号 |
A61K31/335;A61K31/34;A61K31/365;A61K31/381;A61K31/4178;A61K31/422;A61K31/427;A61K31/4427;A61P35/00;C07D313/00;C07D405/06;C07D407/06;C07D409/06;C07D413/06;C07D417/06;C07D417/14;C07D493/04 |
主分类号 |
A61K31/335 |
| 代理机构 |
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