发明名称 |
Methods for modulating metabolic pathways of micro-organisms and micro-organismsobtainable by said methods |
摘要 |
The invention provides methods for changing the metabolic pathways of micro-organisms in the presence of a certain carbon source and uses of such changes, as well as micro-organisms and uses of such changes, as well as micro-organisms produced by these methods. In a preferred embodiment the invention provides new yeast strains with improved biomass yields, a process to obtain these yeasts and the potential application of these yeasts are provided. The biomass yield is improved by the introduction into a yeast of a DNA construct conferring altered expression of a gene encoding a protein controlling transcription of a number of glucose-repressed genes. The yeasts are less sensitive to glucose repression, resulting in an increase in respiratory capacity, reduction of ethanol production and increased conversion of sugar into biomass. |
申请公布号 |
AU5346798(A) |
申请公布日期 |
1998.07.03 |
申请号 |
AU19980053467 |
申请日期 |
1997.12.12 |
申请人 |
UNIVERSITEIT VAN AMSTERDAM |
发明人 |
LESLIE ALAN GRIVELL;MAARTEN JOOST TEIXEIRA DE MATTOS;JOLANDA BLOM |
分类号 |
C12N15/09;C07K14/395;C12N1/16;C12N1/19;C12N15/81;C12R1/865 |
主分类号 |
C12N15/09 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|