BIODEGRADABLE TARGETABLE MICROPARTICLE DELIVERY SYSTEM
摘要
Copolymers designed for use as particulate carriers containing functionalizable amino acid subunits for coupling with targeting ligands are described. The copolymers are polyesters composed of alpha -hydroxy acid subunits such as D,L-lactide and pseudo- alpha -amino acid subunits which may be derived from serine or terpolymers of D,L-lactide and glycolide and pseudo- alpha -amino acid subunits which may be derived from serine. Stable vaccine preparations useful as delayed release formulations containing antigen or antigens and adjuvants encapsulated within or physically mixed with polymeric microparticles are described. The particulate carriers are useful for delivering agents to the immune system of a subject by mucosal or parenteral routes to produce immune responses, including antibody and protective responses.
申请公布号
WO9828357(A1)
申请公布日期
1998.07.02
申请号
WO1997CA00980
申请日期
1997.12.19
申请人
CONNAUGHT LABORATORIES LIMITED;SOKOLL, KENNETH, K.;CHONG, PELE;KLEIN, MICHEL, H.