摘要 |
<p>Novel compounds are provided which are inhibitors of MTP and thus are useful for lowering serum lipids and treating atherosclerosis and related diseases, and have structure (I), including pharmaceutically acceptable salts thereof, or prodrug esters thereof, A is (II) or (III) where Z is N or CH, or where Z is (IV) or CH2 when --- is a single bond; Q is (1) -O-; (2) -S-; or (3) (V); B is (VI) or (VII) or (VIII) or (IX) wherein a = 2, 3 or 4 or (X) or (XI) or (XII); and wherein L?1, R, R1, R3, R3', R3a, R3b, R4, R4', R5, R5a¿, X, (XIII), (XIV) and (XV) are as defined herein.</p> |