DERMATOLOGIC PREPARATION

摘要

A dermatologic preparation which is reduced in side effects, has excellent percutaneous absorbability, and contains as the active ingredient an unsaturated fatty acid, which is a triglyceride represented by general formula (1), wherein one or two R1, R2, and R3 each represents a residue of a long-chain unsaturated fatty acid and the remainder represent(s) residue(s) of a medium-chain fatty acid. The triglyceride is preferably represented by formula (1) wherein one of R1, R2, and R3 represents a residue of a long-chain unsaturated fatty acid and the remainder represent(s) residue(s) of a medium-chain fatty acid. The long-chain unsaturated fatty acid is selected from the group consisting of eicosapentaenoic acid, docosahexaenoic acid, docosapentaneoic acid, arachidonic acid, alpha -linolenic acid, gamma -linolenic acid, linoleic acid, and dihomo- gamma -linolenic acid. The most desirable is the eicosapentaenoic acid residue or docosahexaenoic acid residue. The triglyceride is one obtained from a long-chain unsaturated fatty acid and/or a derivative thereof each having a purity of preferably 90 % or higher, more preferably 95 % or higher.