ANTITUMOR ACTIVE SUBSTANCES

摘要

A hot water-insoluble and ethanolic extraction residue component of the fruit bodies of Agaricus blazei Murill belonging to the genus Agaricus is extracted with a 5 % aqueous ammonium oxalate solution, and the extract is decomposed with hydrochloric acid and purified by gel filtration and affinity chromatography to prepare an antitumor active substance comprising fractions respectively having, as measured by gel filtration, a weight average molecular weight of 38 x 10<4> daltons and a degree of dispersion of 2.3, a weight average molecular weight of 29 x 10<4> daltons and a degree of dispersion of 7.3, a weight average molecular weight of 2.4 x 10<4> daltons and a degree of disperion of 4.1, and a weight average molecular weights of 2.0 x 10<4> daltons and a degree of dispersion of 3.6. This substance has significant antitumor effects against solid cancer.