NOVEL CYCLOSPORIN DERIVATIVES, METHOD OF PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

摘要

The invention concerns cyclosporin derivatives of general formula (I) in which Alk is C2-C6 alkylene linear or branched or C3-C6 cycloalkylene and R is: either OH, COOH or alkyloxycarbonyl, or -NR1R2 for which R1 and R2 identical or different are H, or alkyl, C2-C4 alkylene, C3-C6 cycloalkyl, phenyl optionally substituted (by halogen, alkyloxy, alkyloxycarbonyl, amino, alkylamino or dialkylamino), or are benzyl or saturated or unsaturate heterocyclic compound containing 5 or 6 chains and 1 to 3 heteroatoms, or for which R1 and R2 form with the nitrogen atom to which they are bound a heterocyclic compound containing 4 to 6 chains capable of containing another heteroatom selected among N, O or S and optionally substituted by an alkyl, phenyl or benzyl, or a radical of general formula (I') for which R1 and R2 are as defined above, R3 is H or alkyl and n is a whole number from 2 to 4. The alkyl portions or radicals defined above are linear or branched and contain 1 to 4 carbon atoms, as well as their pharmaceutically acceptable salts when they do exist. These novel products are particularly useful for treating and/or preventing retroviral infections.