INHIBITION OF INFLUENZA VIRUS REPLICATION BY OLIGONUCLEOTIDES
摘要
A method of inhibiting influenza virus replication through the activity of natural (unmodified) or modified oligonucleotides (oligodeoxynucleotides or oligoribonucleotides) which hybridize to a selected region of the influenza virus RNA and interfere with its ability to serve as a template for synthesis of encoded products. Oligonucleotides (unmodified or modified) which have antiviral activity against influenza virus as a result of their ability to hydridze to a selected region of influenza virus RNA and inhibit its ability to serve as a template for synthesis of encoded products, as well as compositions which include the oligonucleotides.
申请公布号
EP0527906(B1)
申请公布日期
1998.07.01
申请号
EP19910909830
申请日期
1991.04.29
申请人
THE WORCESTER FOUNDATION FOR BIOMEDICAL RESEARCH, INC.;MOUNT SINAI SCHOOL OF MEDICINE
发明人
AGRAWAL, SUDHIR;LEITER, JOSEF, M., E.;PALESE, PETER;ZAMECNIK, PAUL, C.