Heterocyclic compounds and their use

摘要

PCT No. PCT/DK94/00095 Sec. 371 Date Oct. 31, 1995 Sec. 102(e) Date Oct. 31, 1995 PCT Filed Apr. 4, 1994 PCT Pub. No. WO94/20495 PCT Pub. Date Sep. 15, 1994The present invention relates to therapeutically active azabicyclic compounds of formula (1), wherein Z1 is oxygen or sulphur, a method of preparing the same and to pharmaceutical compositions comprising the compounds. The novel compounds are useful as stimulants of the cognitive function of forebrain and hippocampus of mammals and especially in the treatment of Alzheimer's disease, severe painful conditions and glaucoma. (I)