PROCESSO DE PREPARACAO DE ANALOGOS PSEUDO HEXAPEPTIDOS, HEPTAPEPTIDOS, OCTAPEPTIDOS E NONAPEPTIDOS DA LHRH E DE COMPOSICOES FARMACEUTICAS QUE OS CONTEM

摘要

The present invention relates to the process for preparation of new LHRH analogues. The LHRH analogues include "pseudo" hexapeptide, heptapeptide, octapeptide and nonapeptide LHRH analogues, in which all or some of the amino acids 1, 2 and 3 have been eliminated and the remaining peptide (2-9), (2-10), (3-9), (3-10), (4-9) or (4-10) is bound to various carboxylic acids which take the place of amino acids 1, 2 or 3 in LHRH. The process comprises the coupling of adequately protected amino acids, or of analogues of these amino acids, followed by removal of the protecting groups. The invention also relates to the process for preparation of pharmaceutical compositions.