| 摘要 |
The present invention pertains to a method of preparation of the orally active cephalosporin antibiotic cefixime of formula I, in which at ambient temperature and for a period of 1.5 to 2 hours, one reacts the ester of formula II with inorganic base in a mixture of dimethyl formamide, DMF, and water, isolating the cefixime of required purity by acidification of the resulting reaction mixture and drying. <IMAGE>
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