Combination therapy to treat osteoporosis - polyphosphonates and estrogen agonists

摘要

The present invention provides novel methods of treating or preventing osteoporosis comprising administering to a mammal in need of such treatment an effective amount of a compound of formula I <IMAGE> (I) wherein R1 and R2 may be the same or different provided that, when R1 and R2 are the same, each is a methyl or ethyl group, and, when R1 and R2 are different, one of them is a methyl or ethyl group and the other is hydrogen or a benzyl group; or a pharmaceutically acceptable salt thereof; together with a bone resorption inhibiting polyphosphonate.