发明名称 |
A3 adenosine receptor agonists |
摘要 |
The present invention provides N6-benzyladenosine-5'-N-uronamide and related substituted compounds, particularly those containing substituents on the benzyl and/or uronamide groups, and modified xanthine ribosides, as well as pharmaceutical compositions containing such compounds. The present invention also provides a method of selectively activating an A3 adenosine receptor in a mammal, which method comprises acutely or chronically administering to a mammal in need of selective activation of its A3 adenosine receptor a therapeutically effective amount of a compound which binds with the A3 receptor so as to stimulate an A3 receptor-dependent response.
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申请公布号 |
US5773423(A) |
申请公布日期 |
1998.06.30 |
申请号 |
US19940274628 |
申请日期 |
1994.07.13 |
申请人 |
THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH AND HUMAN SERVICES |
发明人 |
JACOBSON, KENNETH A.;GALLO-RODRIGUEZ, CAROLA;VAN GALEN, PHILIP J. M.;VON LUBITZ, DAG K. J. E.;JEONG, HEAOK KIM |
分类号 |
C07H19/16;(IPC1-7):A61K31/70 |
主分类号 |
C07H19/16 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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