| 摘要 |
<p>PROBLEM TO BE SOLVED: To obtain the subject new compound having slighter adverse effects than existing prostaglandin E1 analog and strong antiulcer action excellent in durability. SOLUTION: This compound is shown by formula I R is H or a 1-4C alkyl; R1 is a group of formula II (R2 is a 1-4C alkyl, a 3-8C alkyl or benzyl) or formula III [one of R3 and R4 is a hydroxyl group and the other is H or methyl; one of R5 and R6 is H or methyl and the other is OR7 (R7 is a 1-4C alkyl, a 3-8C cycloalkyl, benzyl or phenyl)]. The compound of formula I is obtained, for example, by reacting a compound of formula IV (TBS is t-butyldimethylsilyl; R8 is a group in which the hydroxyl of R1 is protected with TBS or a trimethylsilyl group) obtainable by a known method with a compound of formula V and deprotecting the protecting group of the hydroxyl group of the prepared compound by a conventional method.</p> |
