PROCESS FOR THE PREPARATION OF TRANSDERMAL THERAPEUTIC SYSTEM WITH INCREASED RELEASE OF ACTIVE SUBSTANCE

摘要

The invention refers to the process for the preparation of the transdermal therapeutic system with a layered composition consisting of the back layer that is impermeable to the active substance, the matrix with the water insoluble basic material with the divided islands containing the medicinal active substance and the controlling layer which activates the matrix by access of the skin moisture.