PHARMACEUTICAL COMPOSITIONS COMPRISING CONTIGNASTEROL COMPOUNDS.

摘要

PCT No. PCT/CA93/00558 Sec. 371 Date Sep. 5, 1995 Sec. 102(e) Date Sep. 5, 1995 PCT Filed Dec. 21, 1993 PCT Pub. No. WO94/14451 PCT Pub. Date Jul. 7, 1994Steroid compounds of the contignasterol family, including stereoisomers and pharmaceutically acceptable salts, as well as compositions containing these materials and a pharmaceutically acceptable carrier, are disclosed. The steroid compounds have a 3 alpha -hydroxyl, a 4 beta -hydroxyl, a 6 alpha -hydroxyl, a 7 beta -hydroxyl, a 15-ketone, a trans A/B ring juncture and a cis or trans C/D ring juncture. The compounds and compositions may be used, for example, for the prevention of inflammatory or allergic reactions, or the treatment of cardiovascular or haemodynamic disorders.