| 摘要 |
PROBLEM TO BE SOLVED: To obtain a new daunomycinone or adriamycinone derivative (acid adduct) having an anticancer activity, excellent in water solubility and useful as an antitumor medicine, etc. SOLUTION: A compound of formula I (R is H, hydroxyl). For example, 7-O-(4-amino-2,4,6-trideoxy-2-fluoro-α-L-talopyranosyl)daunomycin. The compound of formula I is obtained e.g. by condensing daunomycinone of formula II with a 3,4-di-O,N-protected-4-amino-2,4,6-trideoxy-2-fluoro-L-talopyranosyl halide of formula III (Y' is acetyl, benzoyl; Y" is trifluoroacetyl; X is bromine, iodine) and subsequently removing the hydroxyl-protecting group and the amino- protecting group from the produced compound of formula IV.
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