N-SULFONYLTYROSINE 4-(4-PYRIDYL)-BUTYL ESTER OR ITS PHARMACEUTICALLY ACCEPTABLE SALTS AND A METHOD OF SYNTHESIS OF N-SULFONYLTYROSINE 4-(4-PYRIDYL)-BUTYL ESTER OR ITS PHARMACEUTICALLY ACCEPTABLE SALTS

摘要

FIELD: organic chemistry. SUBSTANCE: product: N-sulfonyltyrosine 4-(4-pyridyl)-butyl ester of the formula (I) C4H9SO2Cl or its pharmaceutically acceptable salts. Reagent 1: tyrosine. Reagent 2: n-Br(CH2)4Cl. Reagent 3: methylated pyridine. Reagent 4: . Product of interaction of reagents 1 and 2 is subjected for reaction with product of interaction of reagents 3 and 4. Reaction conditions: in the presence of alkali. Product of the formula (I) is subjected for selective hydrogenation using Pd/C in acetic acid and product of the formula (II) is obtained. Synthesized compound is used in medicine as an antagonist of fibrinogen receptors. EFFECT: improved method of synthesis. 4 cl, 1 exv