发明名称 |
L-2'-DEOXY-2'-FLUORO-NUCLEOSIDE AND NUCLEOTIDE DERIVATIVES |
摘要 |
A method for the treatment of a host, and in particular, a human, infected with HBV or EBV is provided that includes administering an HBV- or EBV- treatment amount of an L-nucleoside of formula (I) <CHEM> wherein R is a purine or pyrimidine base. In one preferred embodiment, the active compound is 2'-fluoro-5-methyl- beta -L-arabinofuranosyluridine (also referred to as L-FMAU) This compound is a potent antiviral agent against HBV and EBV and exhibits low cytotoxicity. Other specific examples of active compounds include N1-(2'-deoxy-2'-fluoro- beta -L-arabinofuranosyl)-5-ethyluracil, N1-(2'-deoxy-2'-fluoro- beta -L-arabinofuranosyl)-5-iodocytosine), and N1-(2'-deoxy-2'-fluoro- beta -L-arabinofuranosyl)-5-iodouracil. <IMAGE>
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申请公布号 |
NZ281058(A) |
申请公布日期 |
1998.06.26 |
申请号 |
NZ19950281058 |
申请日期 |
1995.01.30 |
申请人 |
UNIVERSITY OF GEORGIA RESEARCH FOUNDATION INC;YALE UNIVERSITY |
发明人 |
CHU, CHUNG K;CHENG, YUNG-CHI;PAI, BALAKRISHNA S;YAO, GANG-QING |
分类号 |
C07H19/09;A61K31/70;A61K31/7042;A61K31/7052;A61K31/7064;A61K31/7068;A61K31/7072;A61K31/7076;A61P31/12;C07H19/06;C07H19/16;C07H19/19;C07H21/00;(IPC1-7):C07H19/00;C07H19/20 |
主分类号 |
C07H19/09 |
代理机构 |
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