| 摘要 |
The invention concerns cyclosporin derivatives characterised in that they comply with general formula (I) in which Alk is C2-C6 alkylene linear or branched or C3-C6 cycloalkylene and R is: either COOH or alkyloxycarbonyl, or -NR1R2 for which R1 and R2 identical or different are H, or alkyl, C2-C4 alkylene, C3-C6 cycloalkyl, phenyl optionally substituted (by halogen, alkyloxy, alkyloxycarbonyl, amino, alkylamino or dialkylamino) or are benzyl or saturated or unsaturated heterocyclic compound radicals containing 5 or 6 chains and 1 to 3 heteroatoms, or for which R1 and R2 form with the nitrogen atom to which they are bound a heterocyclic compound containing 4 to 6 chains capable of containing another heteroatom selected among N, O and S and optionally substituted by an alkyl, phenyl or benzyl, or a radical of general formula (I') for which R1 and R2 are defined as above, R3 is H or alkyl and n is a whole number from 2 to 4. The alkyl portions or radicals defined above are linear or branched and contain 1 to 4 carbon atoms as well as their pharmaceutically acceptable salts when they exist. These novel products are particularly useful for treating and or preventing retroviral infections.
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