Endothelin-Rezeptor-Antagonisten

摘要

New compounds of the formula (I), in which R is an unsubstituted, an R<3> mono-, di-, or trisubstituted, or an R<5> substituted phenyl, or unsubstituted or simply R<2> substituted 2,1,3-benzothiadiazolyl; R<1> is A, in which 1-7 H atoms can be replaced by F, -S-A, -A-A, unsubstituted or simply R<3> substituted phenyl, -alkylene-phenyl or unsubstituted or simply R<3> substituted thienyl; R<2> is A, F, Cl, Br or -O-A; R<3>, R<4>, R<5> are, independently, A, -O-A, -S-A, -O-alkylene-COOH, -alkylene-COOH or COOH; R<3> and R<4> together can also mean -O-CH2-O-; and A is alkyl with 1-7 C atoms, as well as their salts, have endothelin receptors antagonistic properties.