VACCINE FOR THE REVERSIBLE IMMUNOCASTRATION OF MAMMALS

摘要

The invention relates to the field of genetic engineering and biotechnology and particularly to the use of a peptide derived from GnRH for the immunocastration of mammals. Vaccinations tests have been carried out in mammals with the gonadotropine release hormone (GnRH), in order to ellicit and immune response which neutralizes the activity of said hormone. The present invention relates to the use of a GnRH variant of mammals wherein a glycin residue has been substituted by a prolin residue in position 6: Glu-His-Trp-Ser-Tyr-Pro-Leu-Arg-Pro-Gly. This substitution or change has induced an immune response which is superior than that of natural GnRH, when both are coupled to a same carrier protein, in experiments carried out in pigs. This same result can be expected in any other mammal since this hormone is present in all species.