SITE-SPECIFIC CONTROLLED RELEASE DOSAGE FORMULATION FOR MESALAMINE

摘要

Pharmaceutical formulation for the site-specific delivery of mesalamine in the colon is disclosed. The formulation includes (a) a core comprising mesalamine in an amount effective to produce a therapeutic anti-inflammatory effect; (b) a swellable polymeric coating layer substantially surrounding the core which inhibits the release of mesalamine for a predetermined period of time dependent upon the thickness of the swellable polymeric coating layer, and (c) an outer enteric coating layer substantially surrounding the swellable polymeric coating layer. Methods of achieving the site-specific delivery of mesalamine in the colon are also disclosed.