HUMAN AND MAMMALIAN DNA REPLICATION ORIGIN CONSENSUS SEQUENCES
摘要
The present invention relates to a human or mammalian DNA replication origin consensus sequence which consists of a sequence selected from the group consisting of CCTMDAWKSGBYTSMAAWYWBCMYTTRSCAAATTCC (SEQ ID NO:1); and AWMTWAAKRAWRWWKKDAVWWGAKRWWKWVWHRASSACMDWKAAKTWKGGWTWARRYWKGRKMWWTWKAWSDATAKWWWKDAKWKMWRKTT (SEQ ID NO:4). A method for the control of initiation of mammalian DNA replication which comprises the steps of: a) inserting a consensus sequence coding for a sequence of the present invention together with a DNA fragment to form a vector capable of expression of the DNA fragment; b) introducing the vector of step a) into mammalian cells in vitro.
申请公布号
WO9827200(A2)
申请公布日期
1998.06.25
申请号
WO1997CA00972
申请日期
1997.12.12
申请人
MCGILL UNIVERSITY;PRICE, GERALD, B.;ZANNIS-HADJOPOULOS, MARIA;NIELSEN, TORSTEN, O.;COSSONS, NANDINI, H.
发明人
PRICE, GERALD, B.;ZANNIS-HADJOPOULOS, MARIA;NIELSEN, TORSTEN, O.;COSSONS, NANDINI, H.