A process for the preparation of an intermediate useful in the synthesis of iodinated contrast media.

摘要

A process for the preparation of the compound L-5-(2-acetoxypropionylamino)-2,4,6-triiodoisophthaloyl dichloride by reacting 5-amino-2,4,6-triiodoisophthaloyl dichloride with L-2-acetoxyproprionyl chloride in N,N-dimethylacetamide as a solvent, characterized in that a catalytic amount of water is added to the reaction mixture.