| 摘要 |
PROBLEM TO BE SOLVED: To safely and profitably obtain the subject compound at a low cost by reacting the silylation product of a pyrimidine base or purine base with a dialkoxymethane in the presence of acetyl iodide, acethyl bromide or acetyl chloride. SOLUTION: This method for producing an acyclonucleoside of the formula: W-CH2 -O-R (R is a 1-5C alkyl) comprises silylating a compound of the formula: W-H (W is 1-pyrimidinyl or 9-purinyl) an subsequently reacting the product with an dialkoxymethane in the presence of acetyl iodide, acetyl bromide or acetyl chloride. When the acetyl chloride is used, the further addition of a metal iodide compound or a metal bromide compound to the reaction system gives the objective compound in a good yield. Thereby, the objective compound useful as an antiviral agent, an antitumor agent, an antimicrobial agent or an intermediate for synthesizing the agents is obtained. |
