发明名称 |
Phagemids coexpressing a surface receptor and a surface heterologous protein |
摘要 |
PCT No. PCT/US93/08364 Sec. 371 Date Feb. 22, 1995 Sec. 102(e) Date Feb. 22, 1995 PCT Filed Sep. 3, 1993 PCT Pub. No. WO94/05781 PCT Pub. Date Mar. 17, 1994A filamentous phage is described comprising a matrix that includes a heterologous polypeptide fused to a first filamentous phage coat protein membrane anchor and a heterodimeric receptor comprised of first and second receptor polypeptides, wherein one of the receptor polypeptides is fused to a second filamentous phage coat protein membrane anchor. Filamentous phage expressing anchored heterodimeric receptors and dimers of heterologous polypeptides where a first subunit of the dimer is fused to a coat protein membrane anchor and the second subunit of the dimer is soluble heteromeric receptor are also described.
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申请公布号 |
US5770356(A) |
申请公布日期 |
1998.06.23 |
申请号 |
US19950387874 |
申请日期 |
1995.02.22 |
申请人 |
THE SCRIPPS RESEARCH INSTITUTE |
发明人 |
LIGHT, II, JAMES PAUL;LERNER, RICHARD A. |
分类号 |
G01N33/53;C07K14/705;C07K16/00;C07K16/44;C12N1/21;C12N7/01;C12N15/09;C12N15/10;C12P21/02;C12Q1/02;C12Q1/70;C12R1/92;C40B40/02;G01N33/569;(IPC1-7):C12Q1/68;C12N15/64 |
主分类号 |
G01N33/53 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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