发明名称 |
Platelet-specific chimeric 7E3 immunoglobulin |
摘要 |
Platelet-specific, chimeric immunoglobulin and immunoglobulin fragments are described. The chimeric molecules are made up of a nonhuman antigen binding region and a human constant region. Preferred immunoglobulins are specific for glycoprotein IIb/IIIa receptor in its complexed form; they block ligand binding to the receptor and prevent platelet aggregation. The immunoglobulins are useful in anti-thrombotic therapy when administered alone or in conjunction with thrombolytic agents, as well as in thrombus imaging.
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申请公布号 |
US5770198(A) |
申请公布日期 |
1998.06.23 |
申请号 |
US19950375074 |
申请日期 |
1995.01.17 |
申请人 |
THE RESEARCH FOUNDATION OF THE STATE OF NEW YORK;CENTOCOR, INC. |
发明人 |
COLLER, BARRY S.;KNIGHT, DAVID M. |
分类号 |
A61K38/00;A61P7/02;C07K16/28;C12N15/13;(IPC1-7):A61K39/395 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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