发明名称 |
Synthesis of taxol, taxol analogs and their intermediates with variable A-ring side chain structures and compositions thereof |
摘要 |
An efficient protocol for the synthesis of taxol, taxol analogs and their intermediates is described. The process incudes the attachment of the taxol A-ring side chain to baccatin III and for the synthesis of taxol and taxol analogs with variable A-ring side chain structures. A rapid and highly efficient esterification of O-protected isoserine and 3-phenylisoserine acids having N-benzyoloxycarbonyl groups to the C-13 hydroxyl of 7-O-protected baccatin III is followed by a deprotection-acylation sequence to make taxol, celphalomanninne and various analogs, including photoaffinity labeling candidates.
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申请公布号 |
US5770745(A) |
申请公布日期 |
1998.06.23 |
申请号 |
US19940357507 |
申请日期 |
1994.12.15 |
申请人 |
BRYN MAWR COLLEGE |
发明人 |
SWINDELL, CHARLES S.;KRAUSS, NANCY |
分类号 |
C07C271/06;C07C271/22;C07D305/14;C07F7/18;(IPC1-7):C07D305/14 |
主分类号 |
C07C271/06 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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