| 摘要 |
This invention relates to 3-aryl-2-(1-substituted-4-piperidinyl)-1,1-dioxo-3H-benzo[d]isothiazoles and related compounds of formula (I) where X and Y are independently halogen, loweralkyl, loweralkoxy, arylloweralkoxy, acyl, hydroxy, nitro, amino, trifluoromethyl and hydrogen; n, p and q are independently integers of 1 or 2; R is hydrogen, loweralkyl, arylloweralkyl, acyl, -(CH2)m-OR1, -(CH2)mNHR1, formulas (a) and (b), where R1 is hydrogen, loweralkyl, arylloweralkyl, acyl and loweralkoxycarbonyl; Z is hydrogen, halogen, loweralkyl, loweralkoxy and acyl; m is an integer of 2 to 4; s is an integer of 1 or 2; and the pharmaceutically acceptable acid addition salts thereof and the optical isomers thereof where such isomers exist. The compounds of formula (I) of the present invention are useful as modulators of neurotransmitter function such as serotonergic and adrenergic, and as such are useful as antidepressants, and dopaminergic function, and as such may be useful for diseases where the potentiation of dopaminergic activity may be helpful, e.g. Parkinson's Disease. |
