发明名称 |
Novel phenanethridinium derivatives |
摘要 |
A novel phenanthridinium derivative represented by general formula (A): <CHEM> wherein R1 is a substituted or unsubstituted lower aliphatic hydrocarbon group; R is an aliphatic hydrocarbon chain having 2 to 6 carbon atoms which may optionally be substituted with a substituent selected from the group consisting of a lower alkyl group, a halogen and a hydroxy group; each of Y and Z independently represents a hydrogen, a hydroxy or a lower alkoxy group; or Y and Z are combined together to form methylenedioxy or a phenyl ring; and, X<-> is an acid residue or a hydrogen acid residue, exhibits an antitumor activity and has resistance to chemical reduction as well as biological metabolic reactions and is thus advantageous for use as a medicine. |
申请公布号 |
AU4968197(A) |
申请公布日期 |
1998.06.22 |
申请号 |
AU19970049681 |
申请日期 |
1997.11.21 |
申请人 |
NIPPON KAYAKU KABUSHIKI KAISHA |
发明人 |
AKIRA MASUDA;MASATO SUWA;MASANOBU SUZUKI |
分类号 |
C07D221/12;A61K31/435;A61P35/00;C07D471/04;C07D491/056 |
主分类号 |
C07D221/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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