A new ets-related gene overexpressed in human breast and epithelial cancers

摘要

This invention provides for a cDNA that is a coding region of a previously unknown member of the ETS transcription regulator family. The gene described herein (designated ESX) is located at chromosome 1q32 a region amplified in 50% of early breast cancers. The ESX gene of this invention is associated with the etiology of various cancers including breast cancers. Detection of the ESX gene or gene product is thus of diagnostic and/or prognostic value.