Method for improving optical purity of an amine compound

摘要

There is provided a method for improving optical purity of an amine compound of the formula I: wherein R<1> indicates a phenyl group which may be substituted or an aralkyl group having 7 to 10 carbon atoms which may be substituted, and R<2> indicates an alkyl group having 1 to 6 carbon atoms, which is characterized by contacting a cutlture of a microorganism belonging to Arthrobacter having an ability to preferentially metabolize one optical isomer based on an asymmetric carbon atom to which an amino group bonds in the wine compound of the formula I or a treated product thereof with the amine compound of the formula I.