Peptides and compounds that bind to the IL-1 receptor

摘要

Peptides that bind to the interleukin-1 type I receptor (IL-1RtI) can be used to assay the amount of IL-1R, or an IL-1R agonist or antagonist, in a sample and comprise a sequence of amino acids selected from the group consisting of (1) WXXXGZ1W (SEQ ID NO: 2) where Z1 is L, I, A, or Q; (2) XXQZ5YZ6XX where (SEQ ID NO: 1) Z5 is P or Aze where Aze is azetidine; and Z6 is S, A, V, or L; and (3) Z23NZ24SZ25Z26Z27Z28Z29Z30L (SEQ ID NO: 313) where Z23 is D or Y; Z24 is D or S; Z25 is S or W; Z26 is S or Y; Z27 is D or V; Z28 is S or W; Z29 is F or L; and Z30 is D or L; and where each amino acid is indicated by standard one letter abbreviation; and each X can be selected from any one of the 20 genetically coded L-amino acids or the stereoisomeric D-amino acids.