Water-soluble carboxypolysaccharide-magnetic iron oxide complex having a small particle diameter

摘要

PCT No. PCT/JP93/01092 Sec. 371 Date Feb. 6, 1995 Sec. 102(e) Date Feb. 6, 1995 PCT Filed Aug. 4, 1993 PCT Pub. No. WO94/03501 PCT Pub. Date Feb. 17, 1994A water-soluble carboxypolysaccharide-magnetic iron oxide complex of small particle diameter composed of a water-soluble carboxypolysaccharide and a magnetic iron oxide having a core diameter ranging from about 2 to about 7 nm, wherein the total diameter ranges from about 10 to about 50 nm, the ratio of the total diameter to the core diameter is about 15 or less, and the T2-relaxivity ranges from about 10 to about 150 (mM.sec)-1. Said complex has low toxicity and small side effects and is useful in the fields of medical treatment, biology and engineering as an iron-supplementing agent, an X-ray contrast medium, an MRI contrast medium, a reagent for blood flow rate measurement, a carrier for drug administration, etc.