Monoclonal antibodies against type I phospholipase A2 as a diagnostic and anti-inflammatory therapeutic agent

摘要

The invention provides for monoclonal antibodies which specifically bind to type I phospholipase A2 for use as a diagnostic agent and as an anti-inflammatory therapeutic agent, which is particularly suitable for application in acute pancreatitis. The invention further provides for pharmaceutical compositions including the antibodies of the invention. The invention also provides for a method for treating subjects suffering from inflammatory symptoms and for detecting the activity of type I phospholipase A2 in a sample.