Process for obtaining carbetocin and its pharmaceutically acceptable addition salts or complexes.

摘要

Process for obtaining carbetocin and its pharmaceutically acceptable addition salts or complexes. Comprises a simple solid phase synthesis process comprising: 1) Construction of the chain structure with the incorporation of 4-chlorobutyric acid at the terminal amine end, 2) Deprotection of the thiol group of the cisteine and simultaneous breakage of the resin peptide link, 3) Intramolecular cyclization in basic medium by nucleophilic attack by the S- group on the C1 group to form the thioether link.