发明名称 |
CONVERSION OF DELTA 16-STEROID TO A DELTA 17 (20)-20-SILYL ETHER |
摘要 |
The present invention is a process for conversion of .DELTA.16-steroids (I), to the corresponding .DELTA.17(20)-20-silyl ether (III), by reaction with (1) a preformed copper hydride or a metal hydride reducing agent i n the presence of a copper species and (2) a silylating agent. The .DELTA.17(20)-20-silyl ethers (111) are useful intermediat es in the preparation of steroids useful as pharmaceuticals.
|
申请公布号 |
CA2051670(C) |
申请公布日期 |
1998.06.16 |
申请号 |
CA19902051670 |
申请日期 |
1990.05.15 |
申请人 |
PHARMACIA & UPJOHN COMPANY |
发明人 |
SHEPHARD, KENNETH P. |
分类号 |
G01R29/08;C07J5/00;C07J51/00;(IPC1-7):C07J51/00;C07J71/00 |
主分类号 |
G01R29/08 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|